Chemicals and Drugs [D] » Chemical Actions and Uses [D27] » Specialty Uses of Chemicals » Laboratory Chemicals » Indicators and Reagents » Cross-Linking Reagents » Proteolysis Targeting Chimera
Description
Bifunctional molecules that are designed to recruit E3 UBIQUITIN LIGASE to a specific target protein. Proteolysis targeting chimera consist of a target protein ligand connected via a linker to an E3 ligand. They promote association of E3 with specific target proteins tagged for degradation via the PROTEASOME. MeSH
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