Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Oxidoreductases » Oxidoreductases Acting on CH-NH Group Donors » mu-Crystallins
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Eye Proteins » Crystallins » mu-Crystallins
Description
A subclass of crystallins expressed highly in lens of diurnal Australian MARSUPIALS and in neural tissue, muscle, and kidney in humans. It is not a structural protein accounting for the transparency of the human lens unlike other crystallins but instead plays a role in thyroid hormone bioavailability. It is also a cerebral ketimine reductase which reduces cyclic imines (e.g., DELTA(1)-PIPERIDINE-2-CARBOXYLIC ACID; CYSTATHIONINE KETIMINE and LANTHIONINE KETIMINE) in mammalian brain. Mutations in mu-crystallins are associated with an autosomal dominant NONSYNDROMIC DEAFNESS. MeSH
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