Related MeSH Hierarchy (6)
Anatomy [A] » Cells [A11] » Cellular Structures » Intracellular Space » Cell Nucleus » Cell Nucleus Structures » Intranuclear Space » Chromosomes » Chromosome Structures » Telomere » Shelterin Complex
Chemicals and Drugs [D] » Macromolecular Substances [D05] » Multiprotein Complexes » Shelterin Complex
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » DNA-Binding Proteins » Telomere-Binding Proteins » Shelterin Complex
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Nuclear Proteins » Chromosomal Proteins, Non-Histone » Telomere-Binding Proteins » Shelterin Complex
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Nucleoproteins » Shelterin Complex
Phenomena and Processes [G] » Genetic Phenomena [G05] » Genetic Structures » Chromosome Structures » Telomere » Shelterin Complex
Description
A TELOMERE cap complex consisting of telomere-specific proteins in association with telomeric DNA such as telomeric dsDNA-sDNA junction. They are involved in the protection of chromosome ends and TELOMERASE regulation and play a role in CELLULAR SENESCENCE and ageing-related pathology. In general it consists of six mostly TELOMERE-BINDING PROTEINS (POT1, RAP1, TIN2, TPP1, TRF1, and TRF2). MeSH
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