Chemicals and Drugs [D] » Macromolecular Substances [D05] » Multiprotein Complexes » Mitochondrial Permeability Transition Pore
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Membrane Transport Proteins » Mitochondrial Membrane Transport Proteins » Mitochondrial Permeability Transition Pore
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Mitochondrial Proteins » Mitochondrial Membrane Transport Proteins » Mitochondrial Permeability Transition Pore
Description
A multiprotein inner mitochondrial complex which opens only under certain pathological conditions (e.g., OXIDATIVE STRESS) uncoupling the membrane leading to APOPTOSIS and MITOCHONDRIAL TRANSMEMBRANE PERMEABILITY-DRIVEN NECROSIS particularly in CARDIOMYOCYTES during MYOCARDIAL REPERFUSION INJURY. MeSH
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