Related MeSH Hierarchy (5)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Carrier Proteins » Membrane Transport Proteins » Niemann-Pick C1 Protein
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Membrane Transport Proteins » Niemann-Pick C1 Protein
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Receptors, Cell Surface » Patched Receptors » Niemann-Pick C1 Protein
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Receptors, Cell Surface » Receptors, Virus » Niemann-Pick C1 Protein
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Neoplasm Proteins » Tumor Suppressor Proteins » Patched Receptors » Niemann-Pick C1 Protein
Description
A transmembrane intracellular lipid transporter that helps trafficking lipids, particularly cholesterol, from late endosome/lysosome to the ER and plasma membrane. It may also play a role in other cellular cholesterol homeostasis and is an endosomal entry receptor for filoviruses including EBOLAVIRUS. Mutations in the NPC1 are associated with type C NIEMANN-PICK DISEASE. MeSH
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