Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Peptides » Exenatide
Chemicals and Drugs [D] » Complex Mixtures [D20] » Venoms » Exenatide
Chemicals and Drugs [D] » Biological Factors [D23] » Toxins, Biological » Venoms » Exenatide
Description
A synthetic form of exendin-4, a 39-amino acid peptide isolated from the venom of the Gila monster lizard (Heloderma suspectum). Exenatide increases CYCLIC AMP levels in pancreatic acinar cells and acts as a GLUCAGON-LIKE PEPTIDE-1 RECEPTOR (GLP-1) agonist and incretin mimetic, enhancing insulin secretion in response to increased glucose levels; it also suppresses inappropriate glucagon secretion and slows gastric emptying. It is used an anti-diabetic and anti-obesity agent. MeSH
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