Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Transferases » Phosphotransferases » Phosphotransferases (Alcohol Group Acceptor) » Protein Kinases » Protein Serine-Threonine Kinases » WNK Lysine-Deficient Protein Kinase 1
Chemicals and Drugs [D] » Biological Factors [D23] » Antigens » Antigens, Surface » Histocompatibility Antigens » Minor Histocompatibility Antigens » WNK Lysine-Deficient Protein Kinase 1
Chemicals and Drugs [D] » Biological Factors [D23] » Antigens » Isoantigens » Histocompatibility Antigens » Minor Histocompatibility Antigens » WNK Lysine-Deficient Protein Kinase 1
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Intracellular Signaling Peptides and Proteins » Protein Serine-Threonine Kinases » WNK Lysine-Deficient Protein Kinase 1
Description
A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES. MeSH
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