Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Ligases » Ubiquitin-Protein Ligase Complexes » Ubiquitin-Protein Ligases » Tripartite Motif-Containing Protein 28
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » DNA-Binding Proteins » Repressor Proteins » Tripartite Motif-Containing Protein 28
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Transcription Factors » Repressor Proteins » Tripartite Motif-Containing Protein 28
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Tripartite Motif Proteins » Tripartite Motif-Containing Protein 28
Description
A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53. MeSH
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