Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Vesicular Transport Proteins » Endosomal Sorting Complexes Required for Transport » Nedd4 Ubiquitin Protein Ligases
Chemicals and Drugs [D] » Macromolecular Substances [D05] » Multiprotein Complexes » Endosomal Sorting Complexes Required for Transport » Nedd4 Ubiquitin Protein Ligases
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Ligases » Ubiquitin-Protein Ligase Complexes » Ubiquitin-Protein Ligases » Nedd4 Ubiquitin Protein Ligases
Description
E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE. MeSH
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