Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Ubiquitins » NEDD8 Protein
Description
A ubiquitin-like protein that functions in CELL CYCLE regulation and embryogenesis. It is attached covalently to its substrates following activation by the UBIQUITIN-ACTIVATING ENZYME E1-UBA3 enzyme complex. NEDD8 attaches to CULLINS, activating their E3 UBIQUITIN LIGASE activity, to promote polyubiquitination and degradation of CYCLINS and regulatory proteins MeSH
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