Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Peptides » Intracellular Signaling Peptides and Proteins » Apoptosis Regulatory Proteins » DCC Receptor
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Intracellular Signaling Peptides and Proteins » Apoptosis Regulatory Proteins » DCC Receptor
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Receptors, Cell Surface » Netrin Receptors » DCC Receptor
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Neoplasm Proteins » Tumor Suppressor Proteins » DCC Receptor
Description
A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells. MeSH
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