Related MeSH Hierarchy (5)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Parkinson Disease Associated Proteins » High-Temperature Requirement A Serine Peptidase 2
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Hydrolases » Peptide Hydrolases » Endopeptidases » Serine Endopeptidases » High-Temperature Requirement A Serine Peptidase 2
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Hydrolases » Peptide Hydrolases » Serine Proteases » Serine Endopeptidases » High-Temperature Requirement A Serine Peptidase 2
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Intracellular Signaling Peptides and Proteins » Apoptosis Regulatory Proteins » High-Temperature Requirement A Serine Peptidase 2
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Mitochondrial Proteins » High-Temperature Requirement A Serine Peptidase 2
Description
A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE. MeSH
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