Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Neoplasm Proteins » Tumor Suppressor Proteins » Deubiquitinating Enzyme CYLD
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Deubiquitinating Enzymes » Deubiquitinating Enzyme CYLD
Description
A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS. MeSH
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