Related MeSH Hierarchy (5)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Carrier Proteins » Membrane Transport Proteins » Ion Channels » Calcium Channels » TRPC6 Cation Channel
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Carrier Proteins » Membrane Transport Proteins » Ion Channels » Transient Receptor Potential Channels » TRPC Cation Channels » TRPC6 Cation Channel
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Membrane Glycoproteins » Ion Channels » Calcium Channels » TRPC6 Cation Channel
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Membrane Transport Proteins » Ion Channels » Calcium Channels » TRPC6 Cation Channel
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Membrane Transport Proteins » Ion Channels » Transient Receptor Potential Channels » TRPC Cation Channels » TRPC6 Cation Channel
Description
A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2. MeSH
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