Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Ligases » Ubiquitin-Protein Ligase Complexes » Ubiquitin-Protein Ligases » SKP Cullin F-Box Protein Ligases » F-Box-WD Repeat-Containing Protein 7
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Carrier Proteins » F-Box Proteins » F-Box-WD Repeat-Containing Protein 7
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Cell Cycle Proteins » F-Box-WD Repeat-Containing Protein 7
Description
A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES. MeSH
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