Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Lyases » Phosphorus-Oxygen Lyases » Guanylate Cyclase » Soluble Guanylyl Cyclase
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Intracellular Signaling Peptides and Proteins » Guanylate Cyclase » Soluble Guanylyl Cyclase
Description
A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals. MeSH
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