Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Oxidoreductases » Oxidoreductases Acting on CH-NH Group Donors » Oxidoreductases, N-Demethylating » AlkB Homolog 4, Lysine Demethylase
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Oxidoreductases » Oxygenases » Dioxygenases » AlkB Enzymes » AlkB Homolog 4, Lysine Demethylase
Description
A dioxygenase and alkylation repair homolog that mediates demethylation of ACTIN monomethylated at 'Lys-84' (K84me1). Demethylation of actin LYSINE 84 (K84me1) is required for maintaining actin and MYOSIN dynamics to support normal cleavage furrow ingression during CYTOKINESIS and CELL MIGRATION. It may also be involved in transcription regulation. MeSH
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