Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Hydrolases » Aminohydrolases » Nucleoside Deaminases » Cytidine Deaminase » APOBEC Deaminases » APOBEC-3G Deaminase
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Antiviral Restriction Factors » APOBEC-3G Deaminase
Description
An APOBEC deaminase that functions as an inhibitor of RETROVIRIDAE replication and inhibits the mobility of RETROTRANSPOSONS via deaminase-dependent and independent mechanisms. It is selective for SINGLE-STRANDED DNA and does not deaminate double-stranded DNA or single or DOUBLE-STRANDED RNA. It exhibits potent antiviral activity against VIF PROTEIN deficient HIV-1 through the creation of hypermutations in the VIRAL DNA. It also has anti-viral activity against SIMIAN IMMUNODEFICIENCY VIRUSES and HEPATITIS B VIRUS. MeSH
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