Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Lyases » Carbon-Oxygen Lyases » Hydro-Lyases » Carbonic Anhydrases » Carbonic Anhydrase IX
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Carbonic Anhydrase IX
Chemicals and Drugs [D] » Biological Factors [D23] » Antigens » Antigens, Neoplasm » Carbonic Anhydrase IX
Description
A carbonic anhydrase and transmembrane protein that consists of an N-terminal PROTEOGLYCAN-like domain, a catalytic region, a single-pass transmembrane domain, and a short intracellular tail. It functions as a dimer and is expressed primarily by cells of the GASTROINTESTINAL TRACT; BILE DUCT EPITHELIUM; and GALL BLADDER. It is expressed at high levels in many solid tumors, especially CLEAR CELL RENAL CARCINOMA, in response to CELL HYPOXIA. MeSH
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