roxadustat Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

NOW
  • Now
Roxadustat, sold under the brand name Evrenzo, is an anti-anemia medication. Roxadustat is a HIF prolyl-hydroxylase inhibitor that increases endogenous production of erythropoietin and stimulates production of hemoglobin and red blood cells. It was investigated in clinical trials for the treatment of anemia caused by chronic kidney disease (CKD). It is taken by mouth. The drug was developed by FibroGen, in partnership with AstraZeneca.   Wikipedia

Chemistry

  • SMILES: Cc1nc(C(=O)NCC(=O)O)c(O)c2ccc(Oc3ccccc3)cc12
  • InChIKey: YOZBGTLTNGAVFU-UHFFFAOYSA-N
  • Mol. Mass: 352.35
  • ALogP: 2.86
  • ChEMBL Molecule:
    roxadustat  
More Chemistry

Pharmacology

Alternative names

asp1517 | fg-4592 | roxadustat

Organizations (20)

Research & Development (20)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (19)

Approved Indications (1)


 

Kidney Diseases

Experimental Indications - Clinical Trial Phases 1-4 (19)


 

Anemia (Phase 4)

Chronic Kidney Disease-Mineral and Bone Disorder (Phase 4)

Coronary Artery Bypass (Phase 2)

Diabetes Complications (Phase 2)

Dialysis (Phase 2)

Drug-Related Side Effects and Adverse Reactions (Phase 3)

Drugs, Investigational (Phase 1)

Hamartoma (Phase 3)

Healthy Volunteers (Phase 1)

Heart Failure (Phase 4)

Hemodialysis, Home (Phase 3)

Hepatic Insufficiency (Phase 1)

Kidney Diseases (Phase 4)

Kidney Failure, Chronic (Phase 3)

Myelodysplastic Syndromes (Phase 4)

Pharmacokinetics (Phase 1)

Renal Dialysis (Phase 1)

Renal Insufficiency, Chronic (Phase 4)

ST Elevation Myocardial Infarction (Phase 2)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 58
  • # of Trial Organizations: 20

Trials by Phase

Trial Phase Start Date Organizations Indications

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