Active Ingredient History
Prothrombin complex concentrate (PCC), also known as factor IX complex, sold under the brand name Kcentra among others, is a combination medication made up of blood clotting factors II, IX, and X. Some versions also contain factor VII. It is used to treat and prevent bleeding in hemophilia B if pure factor IX is not available. It may also be used for reversal of warfarin therapy. It is given by slow injection into a vein. Wikipedia
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Hemophilia B (approved 1970)
Anticoagulants (Phase 4)
Bleeding Time (Phase 2)
Blood Coagulation (Phase 4)
Blood Coagulation Disorders (Phase 3)
Blood Loss, Surgical (Phase 4)
Blood Transfusion (Phase 2)
Bronchiectasis (Phase 4)
Cardiac Surgical Procedures (Phase 4)
Cardiovascular Surgical Procedures (Phase 4)
Deficiency Diseases (Phase 4)
Fibrin (Phase 2)
General Surgery (Phase 2)
Healthy Volunteers (Phase 1)
Heart Defects, Congenital (Phase 2)
Heart Diseases (Phase 3)
Heart Failure (Phase 3)
Heart Valve Diseases (Phase 4)
Hematologic Diseases (Phase 3)
Hemophilia A (Phase 3)
Hemorrhage (Phase 4)
Hemorrhagic Disorders (Phase 3)
Intracranial Hemorrhages (Phase 4)
Knee Injuries (Phase 4)
Liver Cirrhosis (Phase 4)
Liver Diseases (Phase 4)
Osteoarthritis, Hip (Phase 4)
Pharmacology (Phase 2)
Plasma (Phase 4)
Prostatic Neoplasms (Phase 4)
Shock, Hemorrhagic (Phase 3)
Spinal Dysraphism (Phase 4)
Thrombosis (Phase 4)
Transfusion Reaction (Phase 2)
Transfusion-Related Acute Lung Injury (Phase 2)
Traumatology (Phase 3)
Vitamin K (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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