Active Ingredient History
Nicergoline, sold under the brand name Sermion among others, is an ergot derivative used to treat senile dementia and other disorders with vascular origins. Internationally it has been used for frontotemporal dementia as well as early onset in Lewy body dementia and Parkinson's dementia. It decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs. Unlike many other ergolines, such as ergotamine, nicergoline is not associated with cardiac fibrosis. Wikipedia
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Alzheimer Disease (Phase 4)
Anxiety Disorders (Phase 3)
Dementia (Phase 3)
Dementia, Vascular (Phase 4)
Depression (Phase 3)
Psychophysiologic Disorders (Phase 3)
Schizophrenia (Phase 3)
| Trial | Phase | Start Date | Organizations | Indications |
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