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lanabecestat Report issue

Small molecule Experimental

AACT PubChem

Active Ingredient History

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Lanabecestat is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor. A BACE inhibitor in theory would prevent the buildup of beta-amyloid and may help slow or stop the progression of Alzheimer's disease. ^Wikipedia

Chemistry

SMILES: CC#Cc1cncc(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1
InChIKey: WKDNQONLGXOZRG-HRNNMHKYSA-N
Mol. Mass: 412.54
ALogP: 4.24 Partition coefficient
ChEMBL Molecule:
lanabecestat

More Chemistry

Pharmacology

Mechanism of Action:
- Beta-secretase 1 (Homo sapiens) ^UniProt
Multi-specific: Missing data
Black Box: No
Availability: Missing data
Delivery Methods: Missing data
Pro Drug: No

lanabecestat

Organizations (2)

Research & Development (2)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (4)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (4)

Alzheimer Disease (Phase 3)

Healthy Volunteers (Phase 1)

Liver Diseases (Phase 1)

Renal Insufficiency (Phase 1)

Overview

Highest Phase: Phase 3
# of Trials: 12
# of Trial Organizations: 2

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

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