Active Ingredient History
Iloprost is a second generation structural analog of prostacyclin (PGI) with about ten-fold greater potency than the first generation stable analogs, such as carbaprostacyclin. Iloprost binds with equal affinity to human prostacyclin (Prostanoid IP) and prostaglandin EP1 receptors. Iloprost constricts the ilium and fundus circular smooth muscle as strongly as prostaglandin E2 (PGE2) itself. Iloprost inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time. All of these properties help to antagonize the pathological changes that take place in the small pulmonary arteries of patients with pulmonary hypertension. Used for the treatment of pulmonary arterial hypertension. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Hypertension, Pulmonary (approved 2004)
Acute Lung Injury (Phase 1)
Angioplasty, Balloon, Coronary (Phase 2/Phase 3)
Arterial Occlusive Diseases (Phase 2)
Arteriosclerosis (Phase 2)
Asthma (Early Phase 1)
Bronchi (Phase 2)
Carcinoma (Phase 2)
Coronary Angiography (Phase 2/Phase 3)
COVID-19 (Phase 2)
Diabetes Mellitus (Phase 2)
Healthy Volunteers (Phase 1/Phase 2)
Heart Arrest (Phase 2)
Heart Defects, Congenital (Phase 1/Phase 2)
Heart Failure, Diastolic (Phase 4)
Hypertension (Phase 4)
Hypertension, Pulmonary (Phase 4)
Hypertrophy, Left Ventricular (Phase 2)
Lung Diseases (Phase 1/Phase 2)
Lung Neoplasms (Phase 2)
Multiple Organ Failure (Phase 2)
Myocardial Infarction (Phase 1/Phase 2)
Peripheral Arterial Disease (Phase 4)
Peripheral Nerve Injuries (Phase 2)
Persistent Fetal Circulation Syndrome (Phase 1/Phase 2)
Pneumonia (Phase 2)
Precancerous Conditions (Phase 2)
Pulmonary Arterial Hypertension (Phase 4)
Pulmonary Disease, Chronic Obstructive (Phase 4)
Pulmonary Fibrosis (Phase 2/Phase 3)
Raynaud Disease (Phase 3)
Renal Insufficiency, Chronic (Phase 2/Phase 3)
Respiratory Distress Syndrome (Phase 3)
Respiratory Insufficiency (Phase 2)
Sarcoidosis (Phase 4)
Scleroderma, Systemic (Phase 3)
Sclerosis (Phase 3)
Shock (Phase 3)
Shock, Septic (Phase 2/Phase 3)
Shoulder Fractures (Phase 1/Phase 2)
Trial | Phase | Start Date | Organizations | Indications |
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