fosbretabulin Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

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Fosbretabulin is a microtubule destabilizing experimental drug, a type of vascular-targeting agent, a drug designed to damage the vasculature of cancer tumours causing central necrosis. It is a derivative of combretastatin. It is formulated as the salts fosbretabulin disodium and fosbretabulin tromethamine.   Wikipedia

Chemistry

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Pharmacology

Alternative names

1-(3,4,5-trimethoxyphenyl)-2-(3'-hydroxy-4'-methoxyphenyl)ethene | 2-methoxy-5-((z)-2-(3,4,5-trimethoxyphenyl)vinyl)phenyl dihydrogen phosphate | 3,4,5-trimethoxy-3'-hydroxy-4'-methoxystilbene | ca4dp | combretastatin a4 | combretastatin a-4 | combretastatin a-4 disodium phosphate | combretastatin a-4 phosphate | combretastatin a4 phosphate | crc 87-09 | crc-98-09 | deoxycombretastatin a-4 | fosbretabulin | fosbretabulin disodium | fosbretabulin tromethamine | isocombretastatin a-4 | nsc 817373 | nsc-817373 | phenol, 2-methoxy-5-((1z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-,1-(dihydrogen phosphate) | phenol, 2-methoxy-5-((z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-, dihydrogen phosphate | zybrestat

Organizations (15)

Research & Development (15)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (15)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (15)


 

Central Nervous System Neoplasms (Phase 1)

Choroidal Neovascularization (Phase 2)

Drugs, Investigational (Phase 1/Phase 2)

Everolimus (Phase 1)

Fallopian Tube Neoplasms (Phase 2)

Hamartoma (Phase 2)

Head and Neck Neoplasms (Phase 2)

Livedoid Vasculopathy (Phase 2)

Macular Degeneration (Phase 1/Phase 2)

Myopia, Degenerative (Phase 2)

Neoplasms (Phase 2)

Neuroendocrine Tumors (Phase 2)

Ovarian Neoplasms (Phase 2/Phase 3)

Thyroid Carcinoma, Anaplastic (Phase 3)

Wet Macular Degeneration (Phase 1/Phase 2)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 18
  • # of Trial Organizations: 15

Trials by Phase

Trial Phase Start Date Organizations Indications

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