Active Ingredient History

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Nafamostat mesylate (INN), a synthetic serine protease inhibitor, it is a short-acting anticoagulant, and is also used for the treatment of pancreatitis. It also has some potential antiviral and anti-cancer properties. Nafamostat is a fast-acting proteolytic inhibitor and used during hemodialysis to prevent the proteolysis of fibrinogen into fibrin. The mechanism of action of Nafamostat is as a slow tight-binding substrate, trapping the target protein in the acyl-enzyme intermediate form, resulting in apparent observed inhibition.   Wikipedia

  • SMILES: CS(=O)(=O)O.CS(=O)(=O)O.NC(=N)Nc1ccc(cc1)C(=O)Oc2ccc3cc(ccc3c2)C(=N)N
  • InChIKey: SRXKIZXIRHMPFW-UHFFFAOYSA-N
  • Mol. Mass: 539.59
  • ALogP: 2.65
  • ChEMBL Molecules:
More Chemistry
6'-amidino-2-naphthyl 4-guanidinobenzoate | benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dihydrochloride | fut 175 | fut-175 | nafamostat | nafamostat dihydrochloride | nafamostat dimethanesulfonate | nafamostat hcl | nafamostat hydrochloride | nafamostat mesilate | nafamostat mesylate | nafamstat | nafamstat mesilate | ronastat

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