midodrine (proamatine) Report issue

Small molecule Orphan Drug FDA Approved FDA Accelerated Approval FDA Priority Review FDA

Active Ingredient History

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Midodrine is a prodrug, i.e., the therapeutic effect of orally administered midodrine is due to the major metabolite desglymidodrine formed by deglycination of midodrine. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system. Administration of midodrine results in a rise in standing, sitting, and supine systolic and diastolic blood pressure in patients with orthostatic hypotension of various etiologies. Standing systolic blood pressure is elevated by approximately 15 to 30 mmHg at 1 hour after a 10-mg dose of midodrine, with some effect persisting for 2 to 3 hours. Midodrine has no clinically significant effect on standing or supine pulse rates in patients with autonomic failure. Midodrine forms an active metabolite, desglymidodrine, that is an alpha1-agonist, and exerts its actions via activation of the alpha-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure. Desglymidodrine does not stimulate cardiac beta-adrenergic receptors. Midodrine is used for the treatment of symptomatic orthostatic hypotension (OH). Midodrine is marketed under the brand names Amatine, ProAmatine, Gutron.   NCATS

More Chemistry
  • Mechanisms of Action: Missing data
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: Yes
1-(2',5'-dimethoxyphenyl)-2-glycinamidoethanol | 2-amino-n-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide | (+-)-2-amino-n-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide | a-4020 linz | bramox | dl-n1-(beta-hydroxy-2,5-dimethoxyphenethyl)glycinamid | gutron | midodrin | midodrina | midodrine | (+/-)-midodrine | midodrine hcl | midodrine hydrochloride | midodrine monohydrochloride | midodrinum | midon | proamatine | st-1085 | st-1085 [as the base] | st. peter 224

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