rigosertib Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

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Rigosertib is a synthetic benzyl styryl sulfone in development by Onconova Therapeutics. Rigosertib is in phase III clinical trials for the treatment of chronic myelomonocytic leukemia.   Wikipedia

Chemistry

  • SMILES: COc1cc(OC)c(/C=C/S(=O)(=O)Cc2ccc(OC)c(NCC(=O)O)c2)c(OC)c1
  • InChIKey: OWBFCJROIKNMGD-BQYQJAHWSA-N
  • Mol. Mass: 451.5
  • ALogP: 2.8
  • ChEMBL Molecules:
    rigosertib  
    rigosertib sodium  
More Chemistry

Pharmacology

Alternative names

(n-(2-methyloxy-5-(2',4',6'-trimethoxystyrylsulfonyl)methylenephenyl)amino)acetic acid | n-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide | on01910 | on 01910 | on-01910 | on 01910.na | on-01910.na | rigosertib | rigosertib sodium | sodium (n-(2-methyloxy-5-(2',4',6'-trimethoxystyrylsulfonyl)methylenephenyl)amino)acetate

Organizations (21)

Research & Development (21)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (38)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (38)


 

Adenocarcinoma (Phase 1/Phase 2)

Anemia (Phase 2)

Anemia, Refractory (Phase 3)

Anemia, Refractory, with Excess of Blasts (Phase 3)

Carcinoma, Hepatocellular (Phase 1)

Carcinoma, Non-Small-Cell Lung (Phase 1/Phase 2)

Carcinoma, Squamous Cell (Phase 2)

Epidermolysis Bullosa (Early Phase 1)

Epidermolysis Bullosa Dystrophica (Phase 1/Phase 2)

Esophageal Squamous Cell Carcinoma (Phase 2)

Head and Neck Neoplasms (Phase 1)

Healthy Volunteers (Phase 1)

Leukemia (Phase 2)

Leukemia, Hairy Cell (Phase 1)

Leukemia, Lymphocytic, Chronic, B-Cell (Phase 1)

Leukemia, Myelogenous, Chronic, BCR-ABL Positive (Phase 1/Phase 2)

Leukemia, Myeloid, Acute (Phase 2)

Leukemia, Myelomonocytic, Chronic (Phase 3)

Lung Neoplasms (Phase 2)

Lymphoma, Mantle-Cell (Phase 1)

Melanoma (Phase 2)

Multiple Myeloma (Phase 1)

Myelodysplastic Syndromes (Phase 3)

Myeloproliferative Disorders (Phase 1/Phase 2)

Neoplasm Metastasis (Phase 1)

Neoplasms (Phase 1/Phase 2)

Ovarian Neoplasms (Phase 2)

Pancreatic Neoplasms (Phase 3)

Penile Neoplasms (Phase 2)

Precursor Cell Lymphoblastic Leukemia-Lymphoma (Phase 1/Phase 2)

Primary Myelofibrosis (Phase 2)

Rectal Neoplasms (Phase 2)

Splenomegaly (Phase 2)

Squamous Cell Carcinoma of Head and Neck (Phase 2)

Thrombocytopenia (Phase 3)

Trisomy (Phase 2)

Uterine Cervical Neoplasms (Phase 2)

Waldenstrom Macroglobulinemia (Phase 1)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 38
  • # of Trial Organizations: 21

Trials by Phase

Trial Phase Start Date Organizations Indications

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