oxiglutatione Report issue

Small molecule Approved FDA
ChEMBL DrugBank Drug Central KEGG MeSH PubChem

Active Ingredient History

NOW
  • Now
Oxiglutathione is the oxidized disulfide form of glutathione (GSH) with potential protective activity. Glutathione disulfide (GSSG) is reduced by glutathione reductase to GSH. GSSG and GSH together play important roles in numerous redox reactions, such as those involved in the detoxification of harmful substances and free radicals, and in reactions preventing oxidative damage in erythrocytes. Upon ocular administration in irrigation solution, glutathione disulfide may exert a beneficial effect on the intracellular redox state of glutathione, thereby protecting the integrity and barrier function of the corneal endothelial cells.   NCATS

Chemistry

  • SMILES: [H+].[H+].[Na+].[Na+].N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C([O-])=O)C(=O)NCC([O-])=O)C(=O)NCC([O-])=O)C([O-])=O
  • InChIKey: DRFILBXQKYDTFW-JIWRMXRASA-L
  • Mol. Mass: 656.595
  • ALogP: -3.88
  • ChEMBL Molecule:
    oxiglutatione  
More Chemistry

Pharmacology

Alternative names

nov002 | nov 002 | nov-002 | oxidized glutathione | oxiglutatione

Organizations (2)

Research & Development (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (2)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (1)

Approved Indications (1)


 

Dry Eye Syndromes (approved 2008)

Experimental Indications - Clinical Trial Phases 1-4 (0)

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