benoxinate Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem

Active Ingredient History

NOW
  • Now
Oxybuprocaine (benoxinate) hydrochloride (MINIMS®) is a local, surface anaesthetic of the ester type. It has been shown to give effective surface anaesthesia in short opthalmological procedures. Sensation of pain is locally and reversibly reduced, with the possibility of temperature and pressure sensitivity also affected. Anaesthetic activity is ten times that of cocaine and twice that of tetracaine (amethocaine). Oxybuprocaine (benoxinate) binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.   NCATS

Chemistry

More Chemistry

Pharmacology

Combination drugs

( fluorescein, benoxinate )

Alternative names

4-amino-3-butoxy-2-(diethylamino)ethyl ester benzoic acid | 4-amino-3-butoxy-benzoic acid 2-diethylamino-ethyl ester | 4-amino-3-n-butoxy-benzoesaeure-diaethylaminoaethylester | benoxil | benoxinate | benoxinate dihydrochloride | benoxinate hcl | benoxinate hydrochloride | benoxinate monohydrochloride | bnx | butoxyaminobenzoyldiethylaminoethanol | butoxyprocaine | diethylaminoethyl-4-amino-3-butoxybenzoate | dorsecaine | novescine | novesin | oxibuprocaina | oxibuprocaine chloride | oxybucaine | oxybuprocaine | oxybuprocaine hcl | oxybuprocainum | oxyriprocaine

Organizations (15)

Research & Development (12)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (3)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (5)

Approved Indications (1)


 

Pain (approved 2000)

Experimental Indications - Clinical Trial Phases 1-4 (4)


 

Acute Pain (Early Phase 1)

Anesthetics, Local (Phase 3)

Conscious Sedation (Phase 2)

Myopia (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 11
  • # of Trial Organizations: 12

Trials by Phase

Trial Phase Start Date Organizations Indications

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