deserpidine (harmonyl) Report issue

Small molecule Approved FDA
ChEMBL DrugBank Drug Central Drugs@FDA KEGG PubChem

Active Ingredient History

NOW
  • Now
Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior. Rauwolfia alkaloids work by controlling nerve impulses along certain nerve pathways. As a result, they act on the heart and blood vessels to lower blood pressure. Deserpidine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines.   NCATS

Chemistry

  • SMILES: CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C(NC5=C4C=CC=C5)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)C6=CC(OC)=C(OC)C(OC)=C6
  • InChIKey: CVBMAZKKCSYWQR-WCGOZPBSSA-N
  • Mol. Mass: 578.6527
  • ALogP: 4.16
  • ChEMBL Molecule:
    deserpidine  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Discontinued
  • Delivery Methods: Oral
  • Pro Drug: No

Combination drugs

( deserpidine (harmonyl), methyclothiazide (enduron) - other name: enduronyl forte )
|
( hydrochlorothiazide (esidrix), deserpidine (harmonyl) - other name: oreticyl )

Alternative names

11-demethoxyreserpine | 11-desmethoxyreserpine | (3beta,16beta,17alpha,18beta,20alpha)-17-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester | canescine | deserpidin | deserpidina | deserpidine | deserpidinum | harmonyl | raunormin | raunormine | recanescin | recanescine | reserpidine

Organizations (3)

Research & Development (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (3)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (1)

Approved Indications (1)


 

Hypertension (approved 1957)

Experimental Indications - Clinical Trial Phases 1-4 (0)

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