quinupristin Report issue

Small molecule Approved FDA Accelerated Approval FDA Priority Review FDA
AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
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Quinupristin is an antibiotic compound and a semisynthetic derivative of pristinamycin Ia. Quinupristin is a combination of three peptide macrolactones. Quinupristin is used in combination with dalfopristin, another antibiotic, under the trade name Synercid. Synercid is indicated for treatment of complicated skin and skin structure infections caused by methicillin-susceptible Staphylococcus aureus or Streptococcus pyogenes. The mechanism of action of quinupristin is inhibition of the late phase of protein synthesis in the bacterial ribosome. Quinupristin binds to 23S rRNA within the 50S ribosomal subunit and prevents elongation of the polypeptide as well as causing incomplete chains to be released. Adverse reactions to Synercid include inflammation at infusion site, rash, nausea, vomiting and others.   NCATS

Chemistry

  • SMILES: CC[C@H]1NC(=O)[C@@H](NC(=O)C2=C(O)C=CC=N2)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@@H]3CC(=O)[C@H](CS[C@@H]4CN5CCC4CC5)CN3C(=O)[C@H](CC6=CC=C(C=C6)N(C)C)N(C)C(=O)[C@@H]7CCCN7C1=O)C8=CC=CC=C8
  • InChIKey: WTHRRGMBUAHGNI-LCYNINFDSA-N
  • Mol. Mass: 1022.218
  • ALogP: Missing data
  • ChEMBL Molecule:
    quinupristin  
More Chemistry

Pharmacology

Combination drugs

( quinupristin, dalfopristin (Synercid) - other name: dalfopristin/quinupristin )

Alternative names

5delta-(3-quinuclidinyl)thiomethylpristinamycin ia | quinupristin | quinupristin mesilate | quinupristin mesylate | rp 57669 | rp-57669

Organizations (4)

Research & Development (3)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (2)

Approved Indications (1)


 

Skin Diseases, Infectious (approved 1999)

Experimental Indications - Clinical Trial Phases 1-4 (1)


 

Gram-Positive Bacterial Infections (Phase 3)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 1
  • # of Trial Organizations: 3

Trials by Phase

Trial Phase Start Date Organizations Indications

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