Chemicals and Drugs [D] » Organic Chemicals [D02] » Hydrocarbons » Hydrocarbons, Cyclic » Hydrocarbons, Aromatic » Polycyclic Aromatic Hydrocarbons » Naphthalenes » Lovastatin » Simvastatin
Chemicals and Drugs [D] » Polycyclic Compounds [D04] » Polycyclic Aromatic Hydrocarbons » Naphthalenes » Lovastatin » Simvastatin
Description
A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL. MeSH
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Phase 1 Indicated Drugs (1)
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