Active Ingredient History
Simvastatin is a HMG-CoA Reductase Inhibitor that is FDA approved for the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Common adverse reactions include abdominal pain, constipation, nausea, headache, upper respiratory infection. Cases of myopathy/rhabdomyolysis have been observed with simvastatin co-administered with lipid-modifying doses ( ≥ 1 g/day niacin) of niacin-containing products. The risk of myopathy, including rhabdomyolysis, is increased by concomitant administration of amiodarone, dronedarone, ranolazine, or calcium channel blockers such as verapamil, diltiazem, or amlodipine. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Cardiovascular Diseases (approved 1991)
Acute Coronary Syndrome (Phase 4)
Acute Kidney Injury (Phase 1)
Aging (Phase 4)
Alcoholism (Phase 2/Phase 3)
Alopecia Areata (Phase 1)
Alzheimer Disease (Phase 4)
Anemia, Sickle Cell (Phase 2/Phase 3)
Aortic Valve Stenosis (Phase 3)
Arterial Occlusive Diseases (Phase 2/Phase 3)
Arthritis, Rheumatoid (Phase 4)
Asthma (Phase 3)
Atherosclerosis (Phase 4)
Atrial Fibrillation (Phase 2)
Bariatric Surgery (Phase 4)
Bipolar Disorder (Phase 4)
Bone and Bones (Phase 4)
Bone Diseases (Phase 2)
Bone Regeneration (Phase 2)
Brain Neoplasms (Phase 2)
Breast Neoplasms (Phase 2)
Carcinoma, Hepatocellular (Phase 2)
Carcinoma, Non-Small-Cell Lung (Phase 2)
Carcinoma, Renal Cell (Phase 1)
Cardiomyopathy, Dilated (Phase 2)
Carotid Artery Diseases (Phase 2)
Celiac Disease (Phase 2/Phase 3)
Cerebral Hemorrhage (Phase 2)
Cholangitis, Sclerosing (Phase 3)
Cholesterol (Phase 3)
Cholesterol, HDL (Phase 4)
Cholesterol, LDL (Phase 4)
Choroideremia (Phase 1/Phase 2)
Chronic Pain (Phase 1)
Chronic Periodontitis (Phase 4)
Cognition (Phase 4)
Cognitive Dysfunction (Phase 4)
Colorectal Neoplasms (Phase 3)
Community-Acquired Infections (Phase 4)
Coronary Disease (Phase 4)
Coronary Vasospasm (Phase 1/Phase 2)
Coronavirus Infections (Phase 2)
COVID-19 (Phase 3)
C-Reactive Protein (Phase 3)
Critical Illness (Phase 3)
Cystic Fibrosis (Phase 1/Phase 2)
Dementia, Vascular (Phase 2/Phase 3)
Dental Caries (Phase 1/Phase 2)
Dental Implantation (Phase 1/Phase 2)
Dental Pulp (Phase 2/Phase 3)
Dental Pulp Exposure (Early Phase 1)
Depression (Phase 1/Phase 2)
Depressive Disorder, Major (Phase 4)
Depressive Disorder, Treatment-Resistant (Phase 3)
Diabetes Mellitus (Phase 4)
Diabetes Mellitus, Type 1 (Phase 2)
Diabetic Nephropathies (Phase 4)
Diabetic Neuropathies (Phase 2)
Diabetic Retinopathy (Phase 4)
Drug Interactions (Phase 4)
Drugs, Investigational (Phase 4)
Dyslipidemias (Phase 4)
Emphysema (Phase 4)
Endometriosis (Phase 4)
Endomyocardial Fibrosis (Phase 4)
Endothelial Cells (Phase 4)
Endotoxemia (Phase 1)
Epilepsy (Phase 1)
Erectile Dysfunction (Phase 3)
Esophageal and Gastric Varices (Phase 3)
Essential Hypertension (Phase 4)
Fibrosis (Phase 3)
Fractures, Bone (Phase 3)
Gastric Bypass (Phase 4)
General Surgery (Phase 4)
Glucose Metabolism Disorders (Phase 4)
Graves Ophthalmopathy (Phase 3)
Healthy Volunteers (Phase 4)
Heart Disease Risk Factors (Phase 4)
Heart Diseases (Phase 3)
Heart Failure (Early Phase 1)
Heart Failure, Diastolic (Phase 4)
Hemangioma, Cavernous, Central Nervous System (Early Phase 1)
Hemorrhage (Phase 3)
Hepatitis B (Phase 1)
Hepatitis C, Chronic (Phase 2/Phase 3)
Hepatoblastoma (Phase 1)
HIV (Phase 1)
HIV Infections (Phase 1)
HIV Seronegativity (Phase 1)
Homozygous Familial Hypercholesterolemia (Phase 3)
Hyperglycemia (Phase 4)
Hypertension (Phase 4)
Hypertension, Portal (Phase 4)
Hypertension, Pulmonary (Phase 2)
Hypertriglyceridemia (Phase 4)
Infertility (Phase 3)
Inflammation (Phase 4)
Intermittent Claudication (Phase 2)
Intestinal Neoplasms (Phase 3)
Ischemic Attack, Transient (Phase 2/Phase 3)
Ischemic Stroke (Phase 3)
Kidney Diseases (Phase 4)
Kidney Failure, Chronic (Phase 4)
Kidney Transplantation (Phase 2/Phase 3)
Leiomyoma (Phase 2)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 1)
Lipodystrophy (Phase 1)
Lipoproteins (Phase 4)
Liver Cirrhosis (Phase 4)
Liver Failure (Early Phase 1)
Lung Neoplasms (Phase 2)
Lupus Erythematosus, Systemic (Phase 4)
Lymphangioleiomyomatosis (Phase 1/Phase 2)
Lymphoma (Early Phase 1)
Meniscus (Phase 1/Phase 2)
Mental Disorders (Phase 4)
Mental Health (Phase 4)
Metabolic Syndrome (Phase 4)
Migraine Disorders (Phase 2)
Mucositis (Phase 2)
Multiple Myeloma (Phase 2)
Multiple Sclerosis (Phase 4)
Multiple Sclerosis, Chronic Progressive (Phase 2)
Multiple Sclerosis, Relapsing-Remitting (Phase 3)
Muscle Cramp (Phase 4)
Muscle Weakness (Phase 4)
Musculoskeletal Diseases (Phase 4)
Myocardial Ischemia (Phase 3)
Neoplasm Metastasis (Phase 2)
Neoplasms (Phase 3)
Neoplasms, Germ Cell and Embryonal (Phase 1)
Neuroblastoma (Phase 1)
Noonan Syndrome (Phase 3)
Obesity (Phase 4)
Olfactory Nerve Diseases (Phase 1)
Optic Neuritis (Phase 3)
Osteoporosis (Phase 2)
Osteosarcoma (Phase 1)
Ovarian Neoplasms (Early Phase 1)
Oxidative Stress (Phase 2)
Pain (Phase 4)
Pain, Postoperative (Phase 2/Phase 3)
Pancreatic Neoplasms (Phase 2)
Pancreatitis (Phase 3)
Pancreatitis, Chronic (Early Phase 1)
Parkinson Disease (Phase 2)
Periodontal Diseases (Phase 4)
Periodontitis (Phase 4)
Perioperative Care (Phase 3)
Peripheral Arterial Disease (Phase 4)
Peritoneal Dialysis (Phase 4)
Pharmacology (Phase 1)
Platelet-Rich Fibrin (Phase 1)
Pneumonia (Phase 3)
Polycystic Ovary Syndrome (Phase 4)
Prediabetic State (Phase 2/Phase 3)
Prostatic Neoplasms (Phase 2)
Prostheses and Implants (Phase 2)
Psychotic Disorders (Phase 4)
Pulmonary Disease, Chronic Obstructive (Phase 4)
Renal Insufficiency (Phase 4)
Renal Insufficiency, Chronic (Phase 4)
Respiratory Insufficiency (Early Phase 1)
Retinoblastoma (Phase 1)
Rhabdoid Tumor (Phase 1)
Rhabdomyosarcoma (Phase 1)
Sarcoma, Clear Cell (Phase 1)
Sarcoma, Ewing (Phase 1)
Schizophrenia (Phase 4)
Sepsis (Phase 4)
Shock, Septic (Phase 4)
Simvastatin (Phase 1)
Sinusitis (Phase 2)
Sleep Wake Disorders (Phase 1)
Small Cell Lung Carcinoma (Phase 2)
Smith-Lemli-Opitz Syndrome (Phase 2)
Smoking Cessation (Phase 2)
Smoldering Multiple Myeloma (Phase 2)
Spinal Cord Injuries (Phase 2)
Sprains and Strains (Phase 4)
Stomach Neoplasms (Phase 3)
Stroke (Phase 4)
Subarachnoid Hemorrhage (Phase 2/Phase 3)
Thrombosis (Phase 3)
Thyroid Gland (Phase 3)
Transplantation (Early Phase 1)
Triple Negative Breast Neoplasms (Phase 2)
Tuberous Sclerosis (Phase 1/Phase 2)
Urinary Bladder Neoplasms (Phase 2)
Uveitis (Phase 2/Phase 3)
Vascular Diseases (Phase 3)
Ventilators, Mechanical (Phase 4)
Vitiligo (Phase 2)
Waldenstrom Macroglobulinemia (Phase 2)
Wilms Tumor (Phase 1)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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