trilaciclib (Cosela) Report issue

Small molecule Approved FDA First in Class Breakthrough Therapy FDA Priority Review FDA
AACT PubChem

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Chemistry

Mol. Mass

446.56

ALogP

2.72

Rule of 5

Yes

Rule of 3

No
Details
  • SMILES: CN1CCN(c2ccc(Nc3ncc4cc5n(c4n3)C3(CCCCC3)CNC5=O)nc2)CC1
  • InChIKey: PDGKHKMBHVFCMG-UHFFFAOYSA-N
    InChI=1S/C24H30N8O/c1-30-9-11-31(12-10-30)18-5-6-20(25-15-18)28-23-26-14-17-13-19-22(33)27-16-24(7-3-2-4-8-24)32(19)21(17)29-23/h5-6,13-15H,2-4,7-12,16H2,1H3,(H,27,33)(H,25,26,28,29)
  • Chirality: Achiral Molecule
  • Inorganic: No
  • Polymer: No

Sources

CHEMBL3894860   ChEMBL
trilaciclib

CHEMBL4650272   ChEMBL
trilaciclib dihydrochloride

CDK inhibitor   Wikipedia

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