triciribine Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

NOW
  • Now
Triciribine is a cancer drug which was first synthesized in the 1970s and studied clinically in the 1980s and 1990s without success. Following the discovery in the early 2000s that the drug would be effective against tumours with hyperactivated Akt, it is now again under consideration in a variety of cancers. As PTX-200, the drug is currently in two early stage clinical trials in breast cancer and ovarian cancer being conducted by the small molecule drug development company Prescient Therapeutics.   Wikipedia

Chemistry

  • SMILES: CN1N=C(N)c2cn([C@@H]3O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]3O)c3ncnc1c23
  • InChIKey: URLYINUFLXOMHP-HTVVRFAVSA-N
  • Mol. Mass: 400.29
  • ALogP: -1.77
  • ChEMBL Molecule:
    triciribine phosphate  
More Chemistry

Pharmacology

Alternative names

1,4,5,6,8-pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-o-phosphono-beta-d-ribofuranosyl)- | 1,4,5,6,8-pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-beta-d-ribofuranosyl- | 1,4,5,6,8-pentaazaacenaphthylene-3-amino-1,5-dihydro-5-methyl-1-beta-d-ribofuranosyl 5'-phosphate ester | 3-amino-1,5-dihydro-5-methyl-i-beta-d-ribofuranosyl-1,4,5,6,8- pentaazaacenaphthylene | 6-amino-4-methyl-8-(beta-d-ribofuranosyl)-(4h,8h)pyrrolo(4,3,2-de)pyrimido(4,5-c)pyridazine | 6-arppp | nsc 154020 | nsc-154020 | nsc 154120 | nsc 280594 | nsc-280594 | phosphate salt of tricyclic nucleoside | tcn-monophosphate | tcnp | tcn-p | triciribine | triciribine phosphate | vqd-002

Organizations (6)

Research & Development (6)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (4)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (4)


 

Breast Neoplasms (Phase 1/Phase 2)

Hematologic Neoplasms (Phase 1)

Leukemia (Phase 1)

Ovarian Neoplasms (Phase 1/Phase 2)

Overview

  • Highest Phase: Phase 2
  • # of Trials: 3
  • # of Trial Organizations: 6

Trials by Phase

Trial Phase Start Date Organizations Indications

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