sincalide (kinevac) Report issue

Biologics Peptide Imaging Approved FDA Priority Review FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem

Active Ingredient History

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Sincalide is a synthetically-prepared C-terminal octapeptide of naturally occurring hormone cholecystokinin. Sincalide causes gallbladder contraction and stimulates secretion of pancreatic enzymes, and this property of the drug is used in diagnostic purposes. It is discussed that the drug acts by binding and stimulating the CCK-A receptor which is expressed in the target tissues. FDA approved sincalide under the name KINEVAC.   NCATS

Chemistry

  • SMILES: CSCC[C@H](NC(=O)[C@H](CC1=CC=C(OS(O)(=O)=O)C=C1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](CC2=CNC3=C2C=CC=C3)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC4=CC=CC=C4)C(N)=O
  • InChIKey: IZTQOLKUZKXIRV-YRVFCXMDSA-N
  • Mol. Mass: 1143.269
  • ALogP: Missing data
  • ChEMBL Molecules:
    sincalide  
    pancreozymin  
More Chemistry

Pharmacology

  • Mechanisms of Action:
  • Multi-specific: No
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Parenteral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$28.0370
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Alternative names

cck | cck-33 | cck-8 | cck c-terminal octapeptide | cck-pz | cholecystokinin | cholecystokinin 33 | cholecystokinin-8 | cholecystokinin c-terminal octapeptide | human cck-33 | human cholecystokinin-33 | kinevac | pancreozymin | pankreozymin | sincalide | sq 19844 | sq-19844 | uropancreozymin

Organizations (12)

Research & Development (10)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (2)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (4)

Approved Indications (2)


 

Gallbladder Diseases (approved 1976)

Pancreatic Diseases (approved 1976)

Experimental Indications - Clinical Trial Phases 1-4 (2)


 

Diabetes Mellitus, Type 2 (Phase 4)

Healthy Volunteers (Phase 1)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 9
  • # of Trial Organizations: 10

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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