API | berotralstat

berotralstat (Orladeyo) Report issue

Small molecule Orphan Drug ^FDA Approved ^FDA Fast Track ^FDA

AACT

Active Ingredient History

NOW

Chemistry

SMILES: N#Cc1cccc(C(NCC2CC2)c2ccc(F)c(NC(=O)c3cc(C(F)(F)F)nn3-c3cccc(CN)c3)c2)c1
InChIKey: UXNXMBYCBRBRFD-UHFFFAOYSA-N
Mol. Mass: 562.57
ALogP: 5.7 Partition coefficient
ChEMBL Molecules:

berotralstat

berotralstat hydrochloride

More Chemistry

Pharmacology

Mechanisms of Action:
- Plasma kallikrein (Rattus norvegicus) ^UniProt
- Plasma kallikrein (Homo sapiens) ^UniProt
Multi-specific: Missing data
Black Box: No
Availability: Prescription Only
Delivery Methods: Oral
Pro Drug: No

Drug Pricing (per unit)

United States

$997.3789

More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

bcx7353

Organizations (10)

Research & Development (10)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (1)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (3)

Approved Indications (1)

Angioedemas, Hereditary (approved 2020)

Experimental Indications - Clinical Trial Phases 1-4 (3)

Acne Vulgaris (Phase 3)

Angioedema (Phase 3)

Angioedemas, Hereditary (Phase 3)

Overview

Highest Phase: Phase 3
# of Trials: 12
# of Trial Organizations: 10

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

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