Atosiban (tractocile) Report issue

Small molecule Experimental
AACT ChEMBL Drug Central KEGG MeSH PubChem

Active Ingredient History

NOW
  • Now
Atosiban, sold under the brand name Tractocile among others, is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. It was developed by Ferring Pharmaceuticals in Sweden and first reported in the literature in 1985. Originally marketed by Ferring Pharmaceuticals, it is licensed in proprietary and generic forms for the delay of imminent preterm birth in pregnant adult women.   Wikipedia

Chemistry

  • SMILES: CCOc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1
  • InChIKey: VWXRQYYUEIYXCZ-OBIMUBPZSA-N
  • Mol. Mass: 994.21
  • ALogP: -3.04
  • ChEMBL Molecule:
    atosiban  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Parenteral
  • Pro Drug: No

Alternative names

1-deamino-2-tyr(oet)-4-thr-8-orn-oxytocin | antocin | antocin ii | atosiban | atosiban acetate | (mpa(1)-d-tyr(et)(2)-thr(4)-orn(8))-oxytocin | (mpa(1),d-tyr(et)2,thr(4),orn(8))oxytocin | orf 22164 | orf-22164 | oxytocin, 1-deamino-o-ethyltyrosyl(2)-threonyl(4)-ornithine(8)- | oxytocin, 1-deamino-(o-et-tyr)(2)-thr(4)-orn(8)- | rwj 22164 | rwj-22164 | tractocil | tractocile

Organizations (53)

Research & Development (53)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (9)

Approved Indications (1)


 

Infant, Premature

Experimental Indications - Clinical Trial Phases 1-4 (9)


 

Endometriosis (Phase 2)

Fertilization in Vitro (Phase 2)

Healthy Volunteers (Phase 1)

Infant, Premature (Phase 3)

Infertility (Phase 4)

Labor, Obstetric (Phase 3)

Obstetric Labor, Premature (Phase 4)

Premature Birth (Phase 4)

Prostheses and Implants (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 18
  • # of Trial Organizations: 53

Trials by Phase

Trial Phase Start Date Organizations Indications

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