umbralisib (Ukoniq) Report issue

Small molecule Orphan Drug FDA Approved FDA Breakthrough Therapy FDA Accelerated Approval FDA Priority Review FDA
AACT ChEMBL PubChem

Active Ingredient History

NOW
  • Now
Umbralisib, sold under the brand name Ukoniq, is an anti-cancer medication for the treatment of marginal zone lymphoma (MZL) and follicular lymphoma (FL). It is taken by mouth.   Wikipedia

Chemistry

  • SMILES: CC(C)Oc1ccc(-c2nn([C@@H](C)c3oc4ccc(F)cc4c(=O)c3-c3cccc(F)c3)c3ncnc(N)c23)cc1F
  • InChIKey: IUVCFHHAEHNCFT-INIZCTEOSA-N
  • Mol. Mass: 571.56
  • ALogP: 6.66
  • ChEMBL Molecules:
    umbralisib  
    None  
    umbralisib tosylate  
More Chemistry

Pharmacology

Alternative names

tgr-1202 | umbralisib

Organizations (26)

Research & Development (26)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (18)

Approved Indications (2)


 

Lymphoma, B-Cell, Marginal Zone (approved 2021)

Lymphoma, Follicular (approved 2021)

Experimental Indications - Clinical Trial Phases 1-4 (18)


 

Colorectal Neoplasms (Phase 1)

Esophageal Neoplasms (Phase 1)

Hodgkin Disease (Phase 2)

Intestinal Neoplasms (Phase 1)

Leukemia, Lymphocytic, Chronic, B-Cell (Phase 3)

Lymphoma (Phase 2)

Lymphoma, B-Cell, Marginal Zone (Phase 2/Phase 3)

Lymphoma, Follicular (Phase 2/Phase 3)

Lymphoma, Large B-Cell, Diffuse (Phase 2/Phase 3)

Lymphoma, Mantle-Cell (Phase 2/Phase 3)

Lymphoma, Non-Hodgkin (Phase 2)

Lymphoma, T-Cell, Peripheral (Phase 1)

Pancreatic Neoplasms (Phase 1)

Polycythemia Vera (Phase 1)

Primary Myelofibrosis (Phase 1)

Rectal Neoplasms (Phase 1)

Stomach Neoplasms (Phase 1)

Waldenstrom Macroglobulinemia (Phase 2)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 35
  • # of Trial Organizations: 26

Trials by Phase

Trial Phase Start Date Organizations Indications

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