hyodeoxycholic acid Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

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Hyodeoxycholic acid, also known as 3α,6α-Dihydroxy-5β-cholan-24-oic acid or HDCA, is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria. It differs from deoxycholic acid in that the 6α-hydroxyl is in the 12 position in the former. The 6α-hydroxyl group makes HDCA a hydrophilic acid, a property it shares with hyocholic acid. HDCA is present in mammalian species in different proportions. It is the main acid constituent of hog bile, and for this reason it was used industrially as precursor for steroid synthesis before total synthesis became practical.   Wikipedia

Chemistry

  • SMILES: C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
  • InChIKey: DGABKXLVXPYZII-SIBKNCMHSA-N
  • Mol. Mass: 392.58
  • ALogP: 4.48
  • ChEMBL Molecule:
    hyodeoxycholic_acid  
More Chemistry

Pharmacology

Alternative names

3,6-dihydroxy-5alpha-cholanoic acid | 3 alpha,6 alpha-dihydroxy- 5 beta-cholan-24-oic acid | ahro-001 | hdca | hyodeoxycholic acid | hyodeoxycholic_acid | hyodeoxycholic acid, (3alpha,5beta,6beta)-isomer | hyodeoxycholic acid, (3alpha,6beta)-isomer | hyodeoxycholic acid, sodium salt | hyodesoxycholic acid | murideoxycholic acid | nahdc compound | sodium hyodeoxycholate

Organizations (1)

Research & Development (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

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Indications (1)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (1)


 

Hypercholesterolemia (Phase 1)

Overview

  • Highest Phase: Phase 1
  • # of Trials: 1
  • # of Trial Organizations: 1

Trials by Phase

Trial Phase Start Date Organizations Indications

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