API | narlaprevir

narlaprevir Report issue

Small molecule Experimental

AACT ChEMBL MeSH PubChem

Active Ingredient History

NOW

Narlaprevir, is an inhibitor of NS3/4A serine protease, intended for the treatment of chronic hepatitis C caused by genotype 1 virus in combination with other antiviral drugs. ^Wikipedia

Chemistry

SMILES: CCCC[C@H](NC(=O)[C@@H]1[C@@H]2[C@H](CN1C(=O)[C@@H](NC(=O)NC1(CS(=O)(=O)C(C)(C)C)CCCCC1)C(C)(C)C)C2(C)C)C(=O)C(=O)NC1CC1
InChIKey: RICZEKWVNZFTNZ-LFGITCQGSA-N
Mol. Mass: 707.98
ALogP: 3.62 Partition coefficient
ChEMBL Molecule:
narlaprevir

More Chemistry

Pharmacology

Mechanisms of Action:
- Genome polyprotein (Hepatitis C virus) ^UniProt
- Genome polyprotein (Hepatitis C virus) ^UniProt
- Non-structural protein 4A (Hepatitis C virus) ^UniProt
Multi-specific: Missing data
Black Box: No
Availability: Missing data
Delivery Methods: Missing data
Pro Drug: No

narlaprevir | sch900518 | sch 900518 | sch-900518

Organizations (6)

Research & Development (6)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (5)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (5)

Healthy Volunteers (Phase 1)

Hepacivirus (Phase 2/Phase 3)

Hepatitis C (Phase 3)

Hepatitis C, Chronic (Phase 2/Phase 3)

Liver Diseases (Phase 1)

Overview

Highest Phase: Phase 3
# of Trials: 8
# of Trial Organizations: 6

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

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