menaquinone (vitamin k2) Report issue

Small molecule Experimental
AACT DrugBank Drug Central MeSH PubChem

Active Ingredient History

NOW
  • Now
Vitamin K is a fat-soluble vitamin, which exists in two different forms in nature: vitamin K1 (phylloquinone or phytonadione) and vitamin K2 (menaquinones), a feature of which is a long polyprenyl lateral chain. Menaquinone-7 (MK-7) is a form of vitamin K2 that occurs naturally in some animal-derived and is available as an ingredient of dietary supplements. A novel method of marking five different cis/trans isomers of vitamin K2 (MK-7) (including 6-CIS form) in dietary supplements recently was developed and validated.   NCATS

Chemistry

  • SMILES: CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC1=C(C)C(=O)C2=CC=CC=C2C1=O
  • InChIKey: RAKQPZMEYJZGPI-LJWNYQGCSA-N
  • Mol. Mass: 648.9992
  • ALogP: 14.1
  • ChEMBL Molecule:
    menaquinone 7  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

menaquinone | menaquinone 7 | menaquinone-7 | vitamin k2 | vitamin k2(35) | vitamin mk 7

Organizations (39)

Research & Development (39)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (35)

Approved Indications (1)


 

Osteoporosis

Experimental Indications - Clinical Trial Phases 1-4 (35)


 

Aortic Valve Disease (Phase 2)

Aortic Valve Stenosis (Phase 2)

Arteries (Phase 2)

Atherosclerosis (Phase 2)

Bicuspid Aortic Valve Disease (Phase 2)

Bone Diseases (Phase 2/Phase 3)

Bone Diseases, Metabolic (Phase 1)

Cardiovascular Diseases (Phase 2/Phase 3)

Carotid Artery Diseases (Phase 2)

Chronic Kidney Disease-Mineral and Bone Disorder (Phase 1/Phase 2)

Diabetes Mellitus (Phase 1/Phase 2)

Diabetes Mellitus, Type 2 (Phase 2)

Dietary Supplements ()

Dyslipidemias (Phase 1/Phase 2)

Hemodialysis, Home (Phase 3)

Hyperglycemia (Phase 1/Phase 2)

Hyperlipidemias (Phase 1/Phase 2)

Insulin Resistance (Phase 1/Phase 2)

Kidney Diseases (Phase 4)

Kidney Failure, Chronic (Phase 2/Phase 3)

Multidetector Computed Tomography (Phase 1)

Nutritional and Metabolic Diseases (Phase 1/Phase 2)

Obesity (Phase 1/Phase 2)

Osteoporosis (Phase 1)

Osteoporosis, Postmenopausal (Phase 2/Phase 3)

Pancreas (Phase 1/Phase 2)

Prediabetic State (Phase 1/Phase 2)

Renal Dialysis (Phase 1/Phase 2)

Renal Insufficiency, Chronic (Phase 4)

Thrombosis (Phase 2)

Vascular Calcification (Phase 4)

Vascular Stiffness (Phase 2)

Vitamin K (Phase 2/Phase 3)

Vitamin K 2 (Phase 1)

Vitamin K Deficiency (Phase 1/Phase 2)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 42
  • # of Trial Organizations: 39

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

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