lurbinectedin (Zepzelca) Report issue

Small molecule Orphan Drug FDA Approved FDA Accelerated Approval FDA Priority Review FDA
AACT DrugBank MeSH PubChem

Active Ingredient History

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Lurbinectedin, sold under the brand name Zepzelca, is a medication used for the treatment of small cell lung cancer.   Wikipedia

Chemistry

  • SMILES: COc1ccc2[nH]c3c(c2c1)CCN[C@]31CS[C@@H]2c3c(OC(C)=O)c(C)c4c(c3[C@H](COC1=O)N1[C@@H]2[C@H]2c3c(cc(C)c(OC)c3O)C[C@@H]([C@@H]1O)N2C)OCO4
  • InChIKey: YDDMIZRDDREKEP-HWTBNCOESA-N
  • Mol. Mass: 784.89
  • ALogP: 4.19
  • ChEMBL Molecule:
    lurbinectedin  
More Chemistry

Pharmacology

  • Mechanisms of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Parenteral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$4866.1800
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Alternative names

lurbinectedin | pm01183 | pm 01183 | pm-01183

Organizations (33)

Research & Development (33)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (27)

Approved Indications (1)


 

Small Cell Lung Carcinoma (approved 2020)

Experimental Indications - Clinical Trial Phases 1-4 (27)


 

Breast Neoplasms (Phase 2)

Carcinoma, Neuroendocrine (Phase 2)

Carcinoma, Non-Small-Cell Lung (Phase 2)

Carcinoma, Ovarian Epithelial (Phase 1)

Carcinoma, Transitional Cell (Phase 2)

Colorectal Neoplasms (Phase 1)

Desmoplastic Small Round Cell Tumor (Phase 1/Phase 2)

Endometrial Neoplasms (Phase 1/Phase 2)

Genital Neoplasms, Female (Phase 1)

Glioblastoma (Phase 1)

Homologous Recombination (Phase 2)

Leiomyosarcoma (Phase 2/Phase 3)

Leukemia, Myeloid, Acute (Phase 1)

Liver Diseases (Phase 1)

Lung Neoplasms (Phase 2)

Lymphoma (Phase 1/Phase 2)

Mesothelioma (Phase 2)

Neoplasm Metastasis (Phase 2)

Neoplasms (Phase 2)

Neuroendocrine Tumors (Phase 1/Phase 2)

Ovarian Neoplasms (Phase 3)

Pancreatic Neoplasms (Phase 2)

Sarcoma (Phase 1/Phase 2)

Sarcoma, Ewing (Phase 1/Phase 2)

Small Cell Lung Carcinoma (Phase 3)

Squamous Cell Carcinoma of Head and Neck (Phase 1)

Stomach Neoplasms (Phase 1)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 43
  • # of Trial Organizations: 33

Trials by Phase

Trial Phase Start Date Organizations Indications

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