levomepromazine (levoprome) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem

Active Ingredient History

NOW
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Levomepromazine (also known as methotrimeprazine) is a phenothiazine neuroleptic drug. It is sold in many countries under the generic name (levomepromazine) or under brand names such as Nozinan, Detenler and many more. Levomepromazine is an antipsychotic drug is commonly used as an antiemetic to alleviate nausea and vomiting in palliative care settings particularly in terminal illness. Levomepromazine is a phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. Levomepromazine's antipsychotic effect is largely due to its antagonism of dopamine receptors in the brain. In addition, it can block 5HT2 receptors and some others, like histamine, serotonin.   NCATS

Chemistry

More Chemistry

Pharmacology

Alternative names

(-)-10-(3-(dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine | 2-methoxytrimeprazine | (-)-(2r)-3-(2-methoxy-10h-phenothiazin-10-yl)-n,n,2-trimethylpropan-1-amine | cl-36467 | cl-39743 | hirnamin | levinan | levomeprazine | levomepromazin | levomepromazina | levomepromazine | levomepromazine hcl | levomepromazine hydrochloride | levomepromazine maleate | levomepromazinum | levopromazine | levoprome | levopromethazine | levotomin | mepromazine | methotrimeprazine | methotrimeprazine hydrochloride | nirvan | nozinan | rp-7044 | sk&f-5116 | tisercin | veractil | xp03

Organizations (7)

Research & Development (5)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (2)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (11)

Approved Indications (4)


 

Nausea

Pain (approved 1982)

Sleep Initiation and Maintenance Disorders

Vomiting

Experimental Indications - Clinical Trial Phases 1-4 (7)


 

Anxiety Disorders (Phase 3)

Dementia (Phase 3)

Depression (Phase 3)

Mental Health (Phase 3)

Neoplasms (Phase 4)

Psychophysiologic Disorders (Phase 3)

Schizophrenia (Phase 3)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 4
  • # of Trial Organizations: 5

Trials by Phase

Trial Phase Start Date Organizations Indications

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