idoxuridine (herplex) Report issue

Small molecule Approved FDA Priority Review FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Idoxuridine is an antiviral agent use in keratitis caused by herpes simplex virus. As a prescription drug it comes as a 0.1% ophthalmic solution/drops (Herplex and Dendrid). The first studies of the compound for treatment of human herpes simplex started in early 1960s. Being a structural analog of thymidine idoxuridine inhibits viral DNA replication by substituting thymidine. The effect of idoxuridine results in the inability of the virus to reproduce and/or infect tissues. Idoxuridine also blocks viral thymidine kinase as its substrate analog.   NCATS

Chemistry

  • SMILES: OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(I)C(=O)NC2=O
  • InChIKey: XQFRJNBWHJMXHO-RRKCRQDMSA-N
  • Mol. Mass: 354.0985
  • ALogP: -1.22
  • ChEMBL Molecule:
    idoxuridine  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Topical
  • Pro Drug: No

Alternative names

1-(2-deoxy-beta-d-ribofuranosyl)-5-iodouracil | 1-beta-d-2'-deoxyribofuranosyl-5-iodouracil | 1beta-d-2'-deoxyribofuranosyl-5-iodouracil | 2'-deoxy-5-iodouridine | 5-fluorodeoxyuridine | (+)-5-iodo-2'-deoxyuridine | 5-iodo-2'-deoxyuridine | 5-iododeoxyuridine | 5-iodouracil deoxyriboside | 5iudr | allergan | allergan 211 | allergan-211 | dendrid | herplex | idox | idoxene | idoxuridin | idoxuridina | idoxuridine | idoxuridinum | idu | iododeoxyridine | iododeoxyuridine | iodoxuridine | joddeoxiuridin | kerecid | ophthalmadine | sk&f-14287 | stoxil

Organizations (6)

Research & Development (3)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (3)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (3)

Approved Indications (1)


 

Keratitis, Herpetic (approved 1963)

Experimental Indications - Clinical Trial Phases 1-4 (2)


 

Breast Neoplasms (Phase 1)

Leukemia (Phase 2)

Overview

  • Highest Phase: Phase 2
  • # of Trials: 2
  • # of Trial Organizations: 3

Trials by Phase

Trial Phase Start Date Organizations Indications

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