trametinib (mekinist) Report issue

Small molecule Orphan Drug FDA Approved FDA Fast Track FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

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Chemistry

Mol. Mass

615.4

ALogP

3.94

Rule of 5

No

Rule of 3

No
Details
  • SMILES: CC(=O)Nc1cccc(-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c32)c1
  • InChIKey: LIRYPHYGHXZJBZ-UHFFFAOYSA-N
    InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
  • Chirality: Achiral Molecule
  • Inorganic: No
  • Polymer: No

Sources

CHEMBL2103875   ChEMBL
trametinib *

CHEMBL2105741   ChEMBL
trametinib dimethyl sulfoxide

33E86K87QN   NCATS
trametinib *

Trametinib   Wikipedia

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