furazolidone (furoxone) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem

Active Ingredient History

NOW
  • Now
Furazolidone is a nitrofuran derivarive with broad antibacterial, antiprotazoal properties. It was used for the treatment of bacterial or protozoal enteritis and diarrhea, but now the drug is no longer prescibed in the US. The mechanism of furazolidone action is supposed to be mediated by its binding to bacterial DNA.   NCATS

Chemistry

  • SMILES: [O-][N+](=O)C1=CC=C(O1)\C=N\N2CCOC2=O
  • InChIKey: PLHJDBGFXBMTGZ-WEVVVXLNSA-N
  • Mol. Mass: 225.1583
  • ALogP: 0.97
  • ChEMBL Molecule:
    furazolidone  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Discontinued
  • Delivery Methods: Oral
  • Pro Drug: No

Alternative names

3-{[(5-nitro-2-furanyl)methylene]amino}-2-oxazolidinone | 3-(5'-nitrofurfuralamino)-2-oxazolidone | 3-[(5-nitrofurfurylidene)amino]-2-oxazolidinone | 3-[(5-nitrofurfurylidene)amino]-2-oxazolidone | 3-[(5-nitrofurylidene)amino]-2-oxazolidone | 5-nitro-n-(2-oxo-3-oxazolidinyl)-2-furanmethanimine | diafuron | furall | furaxone | furazol | furazolidinone | furazolidon | furazolidona | furazolidone | furazolidonum | furazon | furidon | furoxone | fzl | n-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone | n-(5-nitro-2-furfurylidene)-3-aminooxazolidine-2-one | nifurazolidone | nitrofurazolidone | nitrofurazolidonum | nitrofuroxon

Organizations (24)

Research & Development (23)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (12)

Approved Indications (2)


 

Diarrhea (approved 1961)

Enteritis (approved 1961)

Experimental Indications - Clinical Trial Phases 1-4 (10)


 

Bacterial Infections (Phase 4)

Disease Eradication (Phase 1)

Dyspepsia (Phase 4)

Gastritis (Phase 4)

Helicobacter pylori (Phase 4)

Medicine, Chinese Traditional (Phase 1)

Peptic Ulcer (Phase 4)

Purpura, Thrombocytopenic, Idiopathic (Phase 2/Phase 3)

Stomach Neoplasms (Phase 4)

Stomach Ulcer (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 31
  • # of Trial Organizations: 23

Trials by Phase

Trial Phase Start Date Organizations Indications

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