Active Ingredient History

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Enzastaurin is a synthetic bisindolylmaleimide with potential antineoplastic activity. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply, preventing growth.   Wikipedia

  • SMILES: Cn1cc(C2=C(C(=O)NC2=O)c3cn(C4CCN(Cc5ccccn5)CC4)c6ccccc36)c7ccccc17
  • InChIKey: AXRCEOKUDYDWLF-UHFFFAOYSA-N
  • Mol. Mass: 515.62
  • ALogP: 4.93
  • ChEMBL Molecules:
More Chemistry
enzastaurin | enzastaurin hcl | enzastaurin hydrochloride | ly317615 | ly-317615 | ly317615.hcl

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