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Diflomotecan is a chemotherapeutic agent that is a topoisomerase inhibitor (Top1). It varies from other camptothecin based Top1 inhibitors like topotecan in having a 7-membered E-ring. The oxepan-2-one ring in the homocamptothecin analogues is more stable in plasma compared to the 6-membered lactone in camptothecin. Diflomotecan was the first homocamptothecin to enter clinical trials and is currently in phase I for treating patients with sensitive small cell lung cancer (SCLC).   Wikipedia

  • SMILES: CC[C@@]1(O)CC(=O)OCC2=C1C=C3N(Cc4cc5cc(F)c(F)cc5nc34)C2=O
  • InChIKey: LFQCJSBXBZRMTN-OAQYLSRUSA-N
  • Mol. Mass: 398.37
  • ALogP: 2.75
  • ChEMBL Molecule:
More Chemistry
bn80915 | bn 80915 | bn-80915 | diflomotecan

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